One of the coolest Xamarin.iOS features is that you can hook your iOS device to the Windows and debug the application very quickly without having to connect it to the Mac and wait ages until the debugger starts up. Unfortunately, an app containing Realm .NET SDKs won't run with this mechanism and will raise an exception.
I would really love to see this working. Considering most of the Xamarin apps I do are using Realm, it's a major productivity killer.